What Is 1,4-Cyclohexanedione CAS 637-88-7? Properties, Uses, and Buying Considerations

1,4-Cyclohexanedione CAS 637-88-7 is a six-membered cyclic diketone used primarily as an organic synthesis intermediate. Its molecular formula is C₆H₈O₂, and its molecular weight is approximately 112.13 g/mol. The molecule contains two ketone groups positioned at the 1 and 4 positions of a cyclohexane ring, giving it useful reactivity for preparing pharmaceutical intermediates, fine chemicals, specialty materials, and research compounds.

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From a purchasing perspective, the chemical name and CAS number are only the starting points. Buyers should also confirm the physical form, assay, water or solvent content, impurity profile, packaging, documentation, and supply scale. At Maison Chemical, we help B2B customers evaluate these details before placing an order so that the selected material matches the intended synthesis and production process.

Key Takeaways

• 1,4-Cyclohexanedione is a cyclic diketone identified by CAS 637-88-7.
• Its commonly referenced molecular formula is C₆H₈O₂, with a molecular weight of about 112.13 g/mol.
• It is mainly purchased as a synthetic building block rather than as a finished active pharmaceutical ingredient.
• Typical applications include pharmaceutical intermediate synthesis, specialty organic synthesis, and laboratory or process development.
• Buyers should qualify each lot through a specification, certificate of analysis, safety documentation, and supply review.

What Is 1,4-Cyclohexanedione?

1,4-Cyclohexanedione is an alicyclic organic compound containing two ketone functional groups on a cyclohexane framework. The 1,4-substitution pattern creates a symmetrical structure that can be useful in transformations involving carbonyl chemistry. Its reactivity may support condensation, reduction, oxidation, substitution, and other synthetic operations, depending on the reaction design and process conditions.

The compound is generally handled as a solid chemical intermediate. A commonly reported melting range is approximately 115–119 °C, although the observed value can depend on purity, physical form, measurement method, and sample history. For this reason, Maison Chemical recommends using the supplier’s current specification and certificate of analysis rather than relying only on catalog values.

Identity and Basic Chemical Data

Core Functions and Chemical Value

The main value of 1,4-cyclohexanedione comes from its two reactive carbonyl groups. These groups can participate in carefully selected reactions that introduce additional functionality or construct more complex cyclic and aromatic structures. The compound therefore serves as a practical starting material for chemists developing multi-step synthesis routes.

Its symmetrical structure can also be valuable during route design. Depending on the target molecule, the two carbonyl positions may be transformed together or used selectively through reaction control and protecting-group strategies. Actual performance depends on the reaction system, catalyst, solvent, temperature, purification method, and the quality grade of the starting material.

Application Scenarios

Pharmaceutical and Medicinal Chemistry

1,4-Cyclohexanedione may be used as an intermediate in the preparation of pharmaceutical building blocks and research compounds. It is not itself a finished drug substance, and its suitability must be assessed against the specific synthetic route. Pharmaceutical development teams commonly review identity, assay, related substances, residual solvents, water content, elemental impurities, and trace-metal requirements when the material enters a controlled development or manufacturing process.

Fine Chemicals and Specialty Synthesis

Fine chemical manufacturers may use this diketone to prepare substituted cyclohexane, cyclohexenone, aromatic, or other functionalized structures. Its use can be relevant to route scouting, process optimization, and the manufacture of small-volume specialty intermediates. The exact application should be confirmed by the customer’s technical team because reaction compatibility cannot be determined from the CAS number alone.

Research and Process Development

Universities, contract research organizations, and industrial laboratories may purchase 1,4-cyclohexanedione for method development or screening. Small-scale research needs may focus on identity and general purity, while process development requires closer attention to lot consistency, packaging, documentation, and repeat availability. A material that works in a gram-scale experiment may still require further qualification before use in kilogram-scale production.

Material Options and Specification Considerations

Not every product listed under the same chemical name will have identical commercial specifications. Differences may involve assay, color, particle characteristics, water content, residual solvents, related organic impurities, and packaging format. Buyers should also check whether the product is supplied as the intended anhydrous material or whether a different physical form, solvated form, or hydrate is being offered.

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For general synthesis, a buyer may establish an internal assay requirement such as not less than 98.0%. This is an example of a purchasing specification, not a universal value or a claim about every commercial lot. For regulated or sensitive applications, the specification should be based on the process risk and supported by batch-specific analytical data.

Documents to Request

• Certificate of analysis for the specific batch
• Safety Data Sheet in the required regional format
• Product specification with test methods where applicable
• Appearance, assay, and impurity information
• Water or residual solvent data when relevant to the process
• Packaging, storage, shelf-life, and transportation information
• Regulatory or customs documents required for the destination market

How B2B Buyers Should Evaluate the Product

1. Define the Intended Use

Start by describing whether the material is for laboratory research, route development, pilot production, or routine manufacturing. The required quality level, documentation, packaging, and supply continuity may differ substantially between these uses. Sharing the application with the supplier allows technical questions to be resolved before quotation and sampling.

2. Confirm Identity and Physical Form

Verify the CAS number, chemical name, molecular formula, and molecular weight on the quotation and technical documents. Ask the supplier to clarify the appearance and physical form, especially if your process depends on dissolution rate, charging behavior, or water sensitivity. If a specific melting range is important, treat it as a lot-specific quality attribute rather than an absolute identity test.

3. Review Quality Data

Compare the proposed specification with your process requirements. In addition to assay, review related substances, moisture, residual solvents, inorganic residues, and analytical method information when these factors could affect downstream reactions. A clear acceptance criterion helps prevent disagreement between the buyer’s quality team and the supplier’s production team.

4. Assess Supply and Packaging

Ask about available pack sizes, minimum order quantity, production or replenishment lead time, and the possibility of repeat supply. Packaging should protect the solid from contamination, moisture, and physical damage during storage and international transportation. The final selection should balance technical suitability with total landed cost, which may include freight, duties, testing, and repacking.

Supplier Support from Maison Chemical

Maison Chemical supplies 1,4-Cyclohexanedione CAS 637-88-7 for customers evaluating pharmaceutical intermediates and specialty chemical applications. We support the purchasing process by clarifying product identity, reviewing specification requirements, organizing batch documentation, and discussing packaging and delivery expectations. Our role is to provide practical information that helps procurement, quality, R&D, and production teams make the same decision from a common technical basis.

For repeat projects, we can discuss forecast quantities, sample evaluation, lot consistency requirements, and the documentation needed for your market or facility. We do not recommend selecting a supplier on price alone, because an apparently lower unit price may not reflect differences in assay, testing, packaging, lead time, or import requirements. A complete quotation should make these factors visible.

Conclusion: Is 1,4-Cyclohexanedione CAS 637-88-7 Right for Your Project?

1,4-Cyclohexanedione CAS 637-88-7 is a cyclic diketone and versatile organic synthesis intermediate with two ketone groups, a molecular formula of C₆H₈O₂, and a molecular weight of approximately 112.13 g/mol. Its principal value is as a building block for pharmaceutical, fine chemical, specialty synthesis, and research applications. The correct grade depends on your reaction route, quality requirements, scale, and documentation needs.

As a next step, prepare your target specification, estimated quantity, destination, required packaging, and application information before requesting a quotation. Maison Chemical can then help you review available material, batch documentation, delivery conditions, and supply options for your project. Contact our B2B team with your requirements to begin a focused evaluation of 1,4-Cyclohexanedione CAS 637-88-7.

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