What Is 1-Methyl-4-pyrazole Boronic Acid Pinacol Ester CAS 761446-44-0? Uses and Sourcing

1-Methyl-4-pyrazole boronic acid pinacol ester, CAS 761446-44-0, is an organoboron compound used as a building block in chemical synthesis. Its pyrazole ring carries a pinacol boronate group, which can serve as a coupling partner in suitable palladium-catalyzed cross-coupling reactions, including Suzuki–Miyaura chemistry. Buyers typically assess it by identity, assay, impurity profile, documentation, and suitability for their specific reaction. At Maison Chemical, we support B2B inquiries by discussing these requirements before confirming a quotation or supply details.

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Key Takeaways

• This compound is a pyrazole-containing boronic acid pinacol ester, also described by its systematic structure as a 1-methyl-1H-pyrazol-4-yl boronate ester.
• Its principal synthetic role is to provide a pyrazole fragment for appropriate carbon–carbon bond-forming reactions.
• The molecular formula is commonly represented as C₁₀H₁₇BN₂O₂, with a calculated molar mass of approximately 208.07 g/mol.
• Before ordering, confirm the required grade, assay method, batch documentation, packaging, quantity, and delivery destination with the supplier.

What Is This Compound?

The product is a boronic acid pinacol ester of a methyl-substituted pyrazole. In practical terms, it combines a nitrogen-containing heteroaromatic ring with a boronate functional group that can participate in selected synthetic transformations. The CAS Registry Number used to identify the material is 761446-44-0.

Its molecular formula is commonly given as C₁₀H₁₇BN₂O₂, and its calculated molar mass is about 208.07 g/mol. This value can help chemists convert a target mass into an approximate molar amount for planning, but it does not establish the assay or usable content of a particular commercial batch. Buyers should use the batch-specific certificate of analysis when calculating quantities for experiments or production.

How the Structure Relates to Its Function

The pyrazole ring is a heterocycle containing two nitrogen atoms, while the pinacol boronate group provides the organoboron functionality. Under suitable reaction conditions, the boronate-bearing carbon can be coupled with an appropriate reaction partner to form a new carbon–carbon bond. The actual outcome depends on the substrate, catalyst, base, solvent, temperature, and other conditions selected by the chemist.

Core Functions and Potential Uses

The material is primarily relevant as a synthetic intermediate rather than as a finished pharmaceutical ingredient. Its value is that it can introduce a 1-methylpyrazole unit into a larger molecular structure through an appropriate coupling route. Researchers may consider it when designing heteroaryl compounds or developing routes to more complex intermediates.

Common Application Scenarios

• Medicinal and discovery chemistry: A potential building block for preparing pyrazole-containing compound libraries or candidate structures. Its use in a particular program depends on the target molecule and validated chemistry.
• Pharmaceutical intermediate development: A possible route component during process research or intermediate synthesis. It should not be treated as an approved drug substance or as evidence of suitability for a regulated process without appropriate evaluation.
• Custom organic synthesis: A coupling partner for research and development where the project requires a methyl-substituted pyrazole motif and the chosen reaction conditions are compatible with a boronate ester.

These are potential chemistry applications, not guarantees of reaction performance. A development team should review compatibility with its substrates and conditions, then confirm conversion, selectivity, impurity formation, and work-up behavior experimentally. For scale-up, process safety and waste handling should also be assessed for the complete reaction system.

Material Options and Specification Considerations

Suppliers may offer the compound in different quantities, packaging formats, or specification levels, subject to availability. These options are commercial or quality-control distinctions and should not be assumed to indicate different chemical identities. Request current product details for the specific lot or offer rather than relying on a generic product description.

What to Confirm in the Specification

A listed purity target or storage condition should be treated as an order-specific specification, not an assumed property of every offer. Boronate ester handling requirements can depend on the material and packaging, so follow the supplied safety data sheet and product documentation. If your process has strict limits for water, residual solvents, or particular impurities, state those limits during the inquiry.

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Buyer Selection Factors

Start with the intended application and define what “acceptable” means for your team. A research laboratory may prioritize a suitable pack size and analytical confirmation, whereas process development may require tighter impurity controls, repeat-batch evaluation, or additional documentation. Neither use case should rely on an unverified product-page statement as a substitute for reviewing the offered batch documents.

Calculate Requirements and Compare Offers

Using the approximate molar mass of 208.07 g/mol, 1 g corresponds to about 4.81 mmol of pure compound. Similarly, 100 g corresponds to approximately 0.481 mol before adjustment for assay, handling loss, or process excess. These calculations are planning examples only; use the actual batch assay and your validated reaction stoichiometry for operational calculations.

When comparing suppliers, review more than the quoted price. Confirm the quoted grade and quantity, whether the price is tied to a specific lot, the documentation included, packaging, dispatch estimate, shipping terms, and any export or import requirements relevant to your location. Request written confirmation for details that affect your purchase decision.

Sourcing from Maison Chemical

Maison Chemical serves B2B customers seeking chemical intermediates and can discuss sourcing requirements for 1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0. Product availability, batch specifications, quantity options, and lead time should be confirmed for the inquiry rather than assumed from a general description. We can review the requested grade and documentation needs so the quotation reflects the buyer’s stated requirements.

Information to Include in an Inquiry

• Product name and CAS number: 761446-44-0.
• Required quantity and preferred packaging, if known.
• Target assay or other critical specification requirements.
• Required documents, such as a batch certificate of analysis or safety data sheet.
• Ship-to country and any timing or regulatory considerations relevant to the order.

Providing these details early helps the supplier check whether the available offer aligns with your intended use. If you have a defined analytical method or impurity threshold, include it so that feasibility can be assessed before purchase. Final acceptance should remain subject to your organization’s technical and quality review of the supplied documentation and material.

Conclusion

1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0 is a pyrazole-containing organoboron building block that may be used in suitable cross-coupling synthesis. Its commonly represented formula is C₁₀H₁₇BN₂O₂, and its approximate molar mass is 208.07 g/mol. To source it responsibly, confirm batch identity, assay, impurity information, documentation, packaging, and delivery terms against your project requirements.

For a B2B quotation from Maison Chemical, send the required quantity, specification, documentation needs, and destination. We can then discuss the available supply details and the next steps for evaluating the material for your application.

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